Mild and occasional heartburn is fairly common, but more frequent heartburn or more severe symptoms generally result in a diagnosis of Gastroesophageal Reflux Disease or GERD. GERD is a serious medical condition that results when stomach contents including acid, bile and enzymes regularly escape into the esophagus (the tube that connects the mouth to the stomach). Because the esophagus does not have the protective mucous lining that the stomach has, it is "burned" by the stomach acid and that's what we recognize as "heartburn".
Under normal circumstances, food is kept in the stomach by the lower esophageal sphincter (LES), a group of several muscles that encircle the esophagus above the stomach that open or relax as food approaches and then reseal. Heartburn results when the LES is unable to prevent the contents of the stomach including hydrochloric acid (HCL), digestive enzymes and bile from escaping into the esophagus. The reason that heartburn hurts is because the esophagus does not have the same protective mucous that the stomach has. The acid, and likely stomach enzymes and bile “burn” the unprotected tissue.
The leading theory on the cause of GERD is that lower esophageal sphincter muscles (that normally provide a barrier between your stomach and esophagus) are weaker in GERD patients and that these muscles relax spontaneously in GERD patients allowing stomach contents to escape into the esophagus. The phenomenon has been termed “transient relaxation of the lower esophageal sphincter” or TRLES. This theory is generally accepted as the underlying cause of GERD by most doctors. But why in the world would these muscles just relax spontaneously? Heartburn Cured documents a new research-based theory that proposes that the root cause of GERD is carbohydrate malabsorption leading to the overgrowth of bacterial in the small intestine. The bacteria produce large amounts of gas and it's the gas that drives acid reflux. The solution is a diet that ensures that carbohydrates are either fully absorbed, or not likely to feed small intestinal bacteria.
Complications of GERD
Scarring and Dysphagia
In addition to the primary symptoms of GERD, there are many secondary complications associated with GERD, some of which are extreme and even life threatening. Repeated GER episodes can result in permanent injury to the esophagus. This scarring can lead to a narrowing of the esophagus referred to as a stricture. This narrowing results in a condition called dysphagia, where swallowing is affected. Dysphagia, can be described as the sensation of food getting stuck in the esophagus after swallowing and often indicates an advanced stage of esophageal damage.
Barrett's syndrome
Over time, untreated reflux esophagitis may lead to the development of Barrett's esophagus. Barrett's esophagus is a metaplastic (precancerous condition that begins in an area where cells have changed into another cell type) process that typically involves the lower esophagus. In trying to repair the damage from acid reflux induced esophageal damage, the esophagus heals in an unusual way. In this case, some of the cells of the esophagus (called squamous cells) are changing to resemble a cell type of the stomach. Barrett's esophagus can, in rare cases, progress to adenocarcinoma (cancer that develops in the lining or inner surface of an organ).
Lung Injury
Gastroesophageal reflux can lead to chronic, severe lung damage and recurrent infections. This GER induced lung injury is caused by the reflux of acid and other intestinal juices into the lungs. Aspiration of gastric juice into the lungs can also lead to what is called pulmonary fibrosis. This is a medical term that means scarring of the lungs. This is a serious condition that can actually require lung transplantation. On a related note, a recent study found that an increased risk of pneumonia was associated with the treatment of GERD with acid reducing medicines. This is covered in chapter three of the book Heartburn Cured.
Why Do So Many Cystic Fibrosis Patients Suffer From GERD?
One of the things a new theory is great for is testing the hypothesis in the real world. The new theory in Heartburn Cured links carbohydrate malabsorption and bacterial overgrowth to acid reflux. The theory proposes that small intestinal bacterial overgrowth (SIBO) fueled by carbohydrate malabsorption results in excess microbial gas production that could drives the reflux of stomach and intestinal contents into the esophagus.